Reply: In vitro culture conditions, antiphospholipid antibodies and trophoblast function

Reply: In vitro culture conditions, antiphospholipid antibodies and trophoblast function.

Sir, WethankDrsClark andLaskin for their interest in our recentlypublished systematic review of the effects of antiphospholipid antibodies on cultured placental cells in vitro.We agreewithmany of the authors’ comments and their suggestions for future investigations. However, in suggesting that trophoblast plugs prevent antiphospholipid antibodies accessing the placenta in early gestation, we be...

LETTERS TO THE EDITOR In vitro culture conditions, antiphospholipid antibodies and trophoblast function

Sir, We read with interest the review of in vitro effects of antiphospholipid antibodies (aPL) on placental cell cultures by Tong et al. (2015).We congratulate the authors on this comprehensive evaluation of the literature to date. Dr Tong and colleagues conceded the limitations on their ability to draw conclusions, notably the heterogeneity of the studies including variable placental models, s...

Novel Mechanisms Of Trophoblast Responses To Antiphospholipid Antibodies And Therapeutics In Obstetric Antiphospholipid Syndrome

Obstetric antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by circulating antiphospholipid antibodies (aPL) and an increased risk of recurrent pregnancy loss and preeclampsia. Current treatments, such as low molecular weight heparin (LMWH) may maintain pregnancy but do not reduce the risk of these late gestational complications. aPL trigger placental inflammation ...

Anticardiolipin and Antiphospholipid Antibodies in Iraqi Patients with Angina Pectoris

Antiphospholipid antibodies from antiphospholipid syndrome patients activate endothelial cells in vitro and in vivo.

BACKGROUND Antiphospholipid (aPL) antibodies are associated with thrombosis in patients diagnosed with antiphospholipid syndrome (APS) and enhance thrombus formation in vivo in mice, but the mechanism of thrombosis by aPL is not completely understood. Although aPL antibodies have been shown to inhibit protein C activation and activate endothelial cells (ECs) in vitro, no study has examined whet...